SPF Vision

The day where all individuals with HSP or PLS are diagnosed, treated and cured.

Welcome to the SPF

HSP and PLS are neurological disorders affecting the voluntary muscles. The disorders are progressive and leads to patients being unable to walk, and more. The Spastic Paraplegia Foundation is dedicated to advancing research and finding the cures for two groups of closely related, progressive neurological disorders: Primary Lateral Sclerosis (PLS) and Hereditary Spastic Paraplegia (HSP).

News & Announcements

  • Cellular Pathways of Hereditary Spastic Paraplegia

    Voluntary movement in humans relies on the pyramidal motor system, a tortuous, multisynaptic pathway in the CNS that extends from the cerebral motor cortex to neuromuscular junctions innervating...

  • Stuck in traffic: an emerging theme in diseases of the nervous system

    The past decade has seen an explosion of DNA sequencing activities and many mutations and genetic variances underlying neurological and neurodegenerative diseases have been determined. This wealth of genetic data is...

  • We Did It!

    Dear Friends, Helen Keller once said: “Although the world is full of suffering, it is full also of the overcoming it.” This takes foresight. It takes courage. It takes love. It takes heros like you. It is such a privilege for me to have the opportunity to be a part of a Foundation that includes...

  • HSP Booklet

    What are the symptoms of HSP? The hallmark of HSP is progressive difficulty walking due to increasingly weak and stiff (spastic) muscles. Symptoms appear in most people between the second and fourth decade of life, but they can start at any age.