Assess Activation of Brain Microglia in ALS with Simultaneous MR-PET

Study Purpose:
This study is being conducted to learn more about inflammation in the brain of people with ALS and PLS. This information could help improve the diagnosis and development of treatments for other patients with ALS or PLS in the future.

Disease: Amyotrophic Lateral Sclerosis (ALS), Familial ALS, Sporadic ALS, Primary Lateral Sclerosis (PLS)

Study Type:
Observational Study

Study Category:
Biomarkers/Imaging

Study Status:
Active, currently recruiting

Study Chair:
Nazem Atassi, MD, MMSc (Massachusetts General Hospital)

Neals Affiliated?
Yes

Coordinating Center Contact:
Massachusetts General Hospital
Paul Cernasov / PCERNASOV@MCLEAN.HARVARD.EDU / 617-726-1880
165 Cambridge Street
Boston, Massachusetts 02114 United States

Full Study Summary:
Massachusetts General Hospital is seeking both people with Amyotrophic Lateral Sclerosis (ALS) and healthy volunteers to participate in an imaging study enrolling under the direction of Dr. Nazem Atassi.

This study is being done to learn more about inflammation in the brain and spinal cord of people with ALS. This can be measured by using Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET). This information may be very valuable for future development of new treatments for ALS.

Study Sponsor:
Neurodegenerative Disease Pilot Study Grant
Participant Duration:
6 visits over 24 months

Estimated Enrollment:
120

Estimated Study Start Date:
04/30/2012

Estimated Study Completion Date:
02/24/2017

Posting Last Modified Date:
12/08/2016

Date Study Added to alsconsortium.org:
11/02/2016