Voluntary movement in humans relies on the pyramidal motor system, a tortuous, multisynaptic pathway in the CNS that extends from the cerebral motor cortex to neuromuscular junctions innervating skeletal muscle. This system is arranged in two main stages (Figure 1). First, axons of large pyramidal neurons originating in layer V of the cerebral motor cortex course through the medullary pyramids, where most fibers decussate in the caudal medulla before descending as lateral corticospinal tracts within the spinal cord. Although some corticospinal axons establish synapses directly with lower motor neurons in the spinal cord anterior horn, the vast majority synapse with spinal interneurons, which then establish connections with lower motor neurons. In the next stage, lower motor neurons terminate in specialized synapses at neuromuscular junctions throughout the body to regulate skeletal muscle contractility.
Giving Tuesday was a great start on our year end goal. So far we have raised over $37,000. Our anonymous donor will match every donation dollar for dollar up to $175,000 until January 15, 2017. That's right, every donation you make will be doubled so you will receive twice as much satisfaction and double the number of people you will help with your wonderful and most appreciated generosity. This is 40% more than was matched last year so we are asking everyone to stretch your giving as well to make sure we use every nickel of this match. We can do it!
When Clinical Trials begin in 2017 it may require as many people as possible for the Clinical Trial to be effective. If you have HSP or PLS, please add your information to our data base so we can keep you informed. We are missing a lot people's email address, so if you just want to add your email address. just enter your name, address and email and we'll add it. That way, we will be able to reach you quickly at a lower cost. Your privacy is very important to us. We will never share any of your information with any individual or company without your permission.
93 cents of every dollar you donate goes into our mission of research and service. 4 cents goes to fundraising and 3 cents goes to data management and general expenses. Our all volunteer Scientific Advisory Board makes sure that we are supporting only the very best research projects on the planet. The Spastic Paraplegia Foundation is an all volunteer run foundation. Our highly skilled staff, Scientific Advisory Board, Medical Advisors - CPA, Attorney, President, Board Members - all of us are working hard every day probono because we strongly believe in this cause. We know we can get to our goal if we all do our very best. We ask you to please join in our efforts by making a donation.