Do people with HSP experience memory loss?

Memory disturbance has been reported in some individuals with HSP due to spastin gene mutations. In general, it was mild. Before attributing memory disturbance to HSP, it is important to consider other causes: stress, anxiety, depression, lack of sleep, medications (including Baclofen), other health conditions including vitamin B12 deficiency. If memory disturbance is significant, a cause of concern, or worsening, it would be important to discuss this with your primary physician and neurologist.