As noted above, PLS is caused by degeneration of the upper motor neurons in the brain and spinal cord. Upper motor neurons control voluntary movement.
The cell bodies of these neurons are located in the motor cortex area of the brain. They have long, hair-like processes called axons that travel to the brainstem and down the spinal cord. Axons relay the messages to move to lower motor neurons that are located all along the brainstem and spinal cord. Lower motor neurons then carry the messages out to the muscles. Click on the diagram at right to see how upper motor neurons connect to lower motor neurons that innervate leg muscles.
When upper motor neurons degenerate, impulses cannot adequately reach the lower motor neurons and the lower motor neurons cannot deliver the proper message to the corresponding muscle. The result is muscle weakness and spasticity. As the degeneration progresses, symptoms increase.
In PLS, the degenerative process impacts the length of the spinal cord, thus affecting the legs, arms and speech and swallowing muscles. For most patients, the process begins in the legs and then travels up the spinal cord. In some people, the process begins in the brainstem, affecting the speech and swallowing muscles first, and then descends down the spinal cord.
We are excited that Giving Tuesday is coming up soon. It is a once a year event and is a perfect accent to the holiday season. Unbeknownst to the commercial world, the holiday season is not about who gets more for me, me, me. It is about that special feeling you get when you know you have really helped out someone you care about or love. It is knowing that the dollar you give today is going to blossom into a million dollars worth of relief from suffering for the people with HSP and PLS. Welcome to Giving Tuesday and we Thank You for your consideration.
When Clinical Trials begin in 2017 it may require as many people as possible for the Clinical Trial to be effective. If you have HSP or PLS, please add your information to our data base so we can keep you informed. We are missing a lot people's email address, so if you just want to add your email address. just enter your name, address and email and we'll add it. That way, we will be able to reach you quickly at a lower cost. Your privacy is very important to us. We will never share any of your information with any individual or company without your permission.
We operate out of the strength of our community, caring friends and sponsors. Your help makes a difference! Our volunteers give many hours of their time annually, and the opportunities to help are as varied as our helpers. Read more.