PLS is diagnosed via a careful clinical examination, by excluding other disorders that cause progressive spasticity and weakness, and by an extended observation period. Tests include a complete neurological examination, blood work, an MRI of the brain and spine, motor and sensory nerve conduction studies, and cerebrospinal fluid analysis. Some of these tests are repeated periodically. Conditions that can be ruled out with testing are tropical spastic paraparesis (TSP), vitamin deficiencies (B12 or E), thoracic spine herniated disks, spinal cord tumors or injury, cerebral palsy, and multiple sclerosis.
Some that may not be ruled out initially include forms of Amyotrophic Lateral Sclerosis where there is no or minimal lower motor neuron involvement, and Hereditary Spastic Paraplegia where there is just lower body and no lower motor neuron involvement. Within a few years, it is evident whether the disorder is actually ALS. Continued observation of clinical symptoms helps differentiate PLS from HSP.
We are excited that Giving Tuesday is coming up soon. It is a once a year event and is a perfect accent to the holiday season. Unbeknownst to the commercial world, the holiday season is not about who gets more for me, me, me. It is about that special feeling you get when you know you have really helped out someone you care about or love. It is knowing that the dollar you give today is going to blossom into a million dollars worth of relief from suffering for the people with HSP and PLS. Welcome to Giving Tuesday and we Thank You for your consideration.
When Clinical Trials begin in 2017 it may require as many people as possible for the Clinical Trial to be effective. If you have HSP or PLS, please add your information to our data base so we can keep you informed. We are missing a lot people's email address, so if you just want to add your email address. just enter your name, address and email and we'll add it. That way, we will be able to reach you quickly at a lower cost. Your privacy is very important to us. We will never share any of your information with any individual or company without your permission.
We operate out of the strength of our community, caring friends and sponsors. Your help makes a difference! Our volunteers give many hours of their time annually, and the opportunities to help are as varied as our helpers. Read more.