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Research

Research Grants 2021 & 2022

2022

I. HSP Grants

  • Stefan Barakat M.D., Ph.D, Clinical Genetics, Erasmus University, Rotterdam, The Netherlands
    Stefan Barakat M.D., Ph.D, Clinical Genetics, Erasmus University, Rotterdam, The Netherlands

    "Exploring therapeutic avenues for a new type of HSP caused by mutations in AMFR: a pilot towards therapy."
    Finding a potential therapy for a rare new form of Hereditary Spastic Paraplegia.

  • Laura Civiero, Ph.D. Associate Professor of Physiology, University of Padova, Italy
    Laura Civiero, Ph.D. Associate Professor of Physiology, University of Padova, Italy

    "Finding novel approaches to rescue pathological phenotypes in ATP13A2-linked Hereditary Spastic Paraplegia."
    Finding novel therapeutic approaches in Hereditary Spastic Paraplegia.

  • Matthias Kneussel, Ph.D., University Medical Center Hamburg-Eppendorf, Germany
    Matthias Kneussel, Ph.D., University Medical Center Hamburg-Eppendorf, Germany

    "Investigating Connections between Tubulin Posttranslational Modifications, Tubular ER Network Integrity and Hereditary Spastic Paraplegia-Related Proteins in Axons."
    How Hereditary Spastic Paraplegia Proteins May Regulate Microtubule-ER Crosstalk for Axonal Health.

  • Claire Pujol, Ph.D, CNRS researcher, Pasteur Institute, Paris, France
    Claire Pujol, Ph.D, CNRS researcher, Pasteur Institute, Paris, France

    "Molecular dissection of mitochondrial dysfunction in HSP by unbiased imaging-based pharmacological and genetic screening."
    Mitochondrial Side Story of HSP disease.


II. PLS Grants

  • Mukesh Gautam, Ph.D, Northwestern University
    Mukesh Gautam, Ph.D, Northwestern University

    "Revealing ultrastructural defects in the motor cortex of PLS patients with and without TDP-43 pathology"
    Revealing cellular problems in the PLS brain.


2021

I. HSP Grants

  • Frederic Darios, Ph.D., and  Alexandra Durr, MD, Ph.D. - ICM-Paris Brain Institute, Paris, France
    Frederic Darios, Ph.D., and Alexandra Durr, MD, Ph.D. - ICM-Paris Brain Institute, Paris, France

    Modulation of mitochondrial function as a modifier of SPG4 physiopathology..

  • Jonathon Howard, Ph.D, Eugene Higgins Professor of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT.
    Jonathon Howard, Ph.D, Eugene Higgins Professor of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT.

    “Roles of alternate isoforms of spastin on function in vitro and in vivo”

  • Roberta La Piana, MD, PhD, Assistant Professor, McGill University, Montreal, QC, Canada
    Roberta La Piana, MD, PhD, Assistant Professor, McGill University, Montreal, QC, Canada

    "Identifying novel white matter diagnostic criteria and imaging biomarkers in Hereditary Spastic Paraplegias (HSPs)”.

  • P. Hande Ozdinler, Ph.D., Associate Professor, Northwestern University, Feinberg School of Medicine, Chicago, IL
    P. Hande Ozdinler, Ph.D., Associate Professor, Northwestern University, Feinberg School of Medicine, Chicago, IL

    "Investigation of NU-9 and its impact on upper motor neurons diseased by spastin mutations in HSP”

  • "Gene therapy, approach forSPG4-based Hereditary Spastic Paraplegia"

II. PLS Grants

  • "Characterizing infratentorial pathology in PLS: the longitudinal evaluation of spinal cord, brainstem and cerebellar pathology in vivo".
    By clicking on Dr. Bede's name above, a compressed file will be downloaded to your computer.

  • Marka van Blitterswijk, M.D., Ph.D., Associate Professor of Neuroscience, Mayo Clinic Jacksonville, FL
    Marka van Blitterswijk, M.D., Ph.D., Associate Professor of Neuroscience, Mayo Clinic Jacksonville, FL

    "Revealing determents of PLS with long read sequencing”.

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