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HSP & PLS
New to SPF?
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Overview
What is an hereditary disorder?
HSP
About HSP
Genetic Information
SPG Numbers and Molecular Pathways
Videos/Blogs/Podcasts
Articles/Papers/Studies
Treatments and Therapies
PLS
SPF Role in PLS Research
PLS Overview
Almost everything you wanted to know about PLS in four minutes
Juvenile PLS
A Work in Progress
Articles/Papers/Studies
Comparison of ALS and PLS
Differences between HSP and PLS
Get Involved
Overview
SPF Survey on HSP/PLS
HSP and PLS Survey Results
Donate Here
Many Ways to Donate
The Power of 12: You’ve Been Challenged
Current Fundraising Campaigns
Estate Planning & Wills
Memorial Giving Honoring Love Ones
A New Research-Giving Initiative
Events
Events Calendar
List of Events
Upper Motor Neurons in Health and Disease
Giving Tuesday/End of the Year Appeal
Awareness Week
Local Events and Fundraisers
5K Run, Walk Roll
Overview
Potato Pants
Past Events / Fundraisers / Connections
SPF Talks
Overview
November 5, 2026
December 3, 2026
Advocacy
Overview
How to Help
Current Campaigns
Related Organizations & Podcasts
Brain & Spinal Cord Donation
Spreading Awareness
Kids & Teens with HSP
Childhood Onset HSP
Kids and Teens with HSP Hanbooks
Coloring Cell and Gene Therapy™
Kids and Teens with HSP
HSP Childhood Onset Survey 2022
HSP Childhood Onset Survey 2026
Current Studies Seeking Participants
Education - Navigating IEPs and 504 Plans
Ambassadors
Overview
Ambassador Volunteer Information
Support Groups
Volunteer on a Committee
SPF Store
Resources
Overview
Join/Update
Directories
Ambassadors
Physician/Clinic Directory
Physical Therapists
Genetic Testing and International Organizations
Genetic Testing
International Organizations
Helpful Websites
HSP San Diego
Bespoke Genetic Medicines - CureSPG75
Our Partner Organizations
Overview
Patient Worthy
Global Genes
Euro-HSP
AEPEF
ASPEC Brasil
Self Help Guides
Stretching and Exercises
Surgical Anesthesia in HSP and PLS
Incontinence
Accessible Parking
Miscellaneous
Newsletter
Synapse
HSP & PLS Informational Documents
Government Aid & Charity Programs
SPF YouTube Channel
Research
Overview
SP-CERN
SP-CERN
SP-CERN LOCATIONS
SP-CERN Research
Current Studies Seeking Participants
Completed Research
Completed Research
Imaging of neuro-inflammation in PLS, HSP, and ALS
Mapping Cortical and Subcortical Degeneration in PLS
Research Grants Funded
Research Grants Funded in 2025
Research Grants Funded between 2021 - 2024
Research Grants Funded Between 2003 - 2020
Submit Proposal
Invitae SP/PLS Insights Network
The Foundation
Overview
Our History
Board of Directors
Scientific Advisory Board
Corporate Documents
Media
Public Service Announcements
Rare Disease Day at NIH 2026
October 17: World HSP/PLS Day
All About World HSP & PLS Day
World HSP & PLS Day - October 17th
World Day Videos
World Day Symbol
Articles/Papers/Studies
These Are Downloadable Documents
HSP Research Papers
The Following Are Not Downloadable
Podcast: CReATe Author Series: Ep. 3 – Dr. Michael Benatar and Neurofilament Biomarkers for ALS
Science Daily Article: How Reticulon 2 & Spastin Interact to Affect the Endoplasmic Reticulum
Every Reason to Hope - Understanding the Current State of HSP Research
Q&A with Allen Bernard & Dr. Craig Blackstone, M.D. , Ph.D about HSP in March 2018
Treating Hereditary Spastic Paraplegia using Traditional Japanese Medicine
Mapping the Natural History of Patients with Hereditary Spastic Paraplegia Type 4
HSP & PLS
New to SPF?
Welcome!
Website Tour
Join/Update
Overview
What is an hereditary disorder?
HSP
About HSP
Genetic Information
SPG Numbers and Molecular Pathways
Videos/Blogs/Podcasts
Articles/Papers/Studies
Treatments and Therapies
PLS
SPF Role in PLS Research
PLS Overview
Almost everything you wanted to know about PLS in four minutes
Juvenile PLS
A Work in Progress
Articles/Papers/Studies
Comparison of ALS and PLS
Differences between HSP and PLS
Get Involved
Overview
SPF Survey on HSP/PLS
HSP and PLS Survey Results
Donate Here
Many Ways to Donate
The Power of 12: You’ve Been Challenged
Current Fundraising Campaigns
Estate Planning & Wills
Memorial Giving Honoring Love Ones
A New Research-Giving Initiative
Events
Events Calendar
List of Events
Upper Motor Neurons in Health and Disease
Giving Tuesday/End of the Year Appeal
Awareness Week
Local Events and Fundraisers
5K Run, Walk Roll
Overview
Potato Pants
Past Events / Fundraisers / Connections
SPF Talks
Overview
November 5, 2026
December 3, 2026
Advocacy
Overview
How to Help
Current Campaigns
Related Organizations & Podcasts
Brain & Spinal Cord Donation
Spreading Awareness
Kids & Teens with HSP
Childhood Onset HSP
Kids and Teens with HSP Hanbooks
Coloring Cell and Gene Therapy™
Kids and Teens with HSP
HSP Childhood Onset Survey 2022
HSP Childhood Onset Survey 2026
Current Studies Seeking Participants
Education - Navigating IEPs and 504 Plans
Ambassadors
Overview
Ambassador Volunteer Information
Support Groups
Volunteer on a Committee
SPF Store
Resources
Overview
Join/Update
Directories
Ambassadors
Physician/Clinic Directory
Physical Therapists
Genetic Testing and International Organizations
Genetic Testing
International Organizations
Helpful Websites
HSP San Diego
Bespoke Genetic Medicines - CureSPG75
Our Partner Organizations
Overview
Patient Worthy
Global Genes
Euro-HSP
AEPEF
ASPEC Brasil
Self Help Guides
Stretching and Exercises
Surgical Anesthesia in HSP and PLS
Incontinence
Accessible Parking
Miscellaneous
Newsletter
Synapse
HSP & PLS Informational Documents
Government Aid & Charity Programs
SPF YouTube Channel
Research
Overview
SP-CERN
SP-CERN
SP-CERN LOCATIONS
SP-CERN Research
Current Studies Seeking Participants
Completed Research
Completed Research
Imaging of neuro-inflammation in PLS, HSP, and ALS
Mapping Cortical and Subcortical Degeneration in PLS
Research Grants Funded
Research Grants Funded in 2025
Research Grants Funded between 2021 - 2024
Research Grants Funded Between 2003 - 2020
Submit Proposal
Invitae SP/PLS Insights Network
The Foundation
Overview
Our History
Board of Directors
Scientific Advisory Board
Corporate Documents
Media
Public Service Announcements
Rare Disease Day at NIH 2026
October 17: World HSP/PLS Day
All About World HSP & PLS Day
World HSP & PLS Day - October 17th
World Day Videos
World Day Symbol
Join/Update
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