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Welcome to Spastic Paraplegia Foundation, Inc.

SPF Vision

The day when all individuals with HSP or PLS are diagnosed, treated, and cured.

HSP and PLS are neurological disorders affecting the voluntary muscles. The disorders are progressive and may lead to patients being unable to walk, and more. The Spastic Paraplegia Foundation is dedicated to advancing research and finding cures for two groups of closely related, progressive neurological disorders: Primary Lateral Sclerosis (PLS) and Hereditary Spastic Paraplegia (HSP).

Learn about our process to fund research for HSP and PLS here.

  • Tour SPF Website and Join our SPF Registry!

  • SPF thrives to accomplish our vision of seeing the day when all individuals with HSP or PLS are diagnosed, treated, and cured.
    Take a look.

  • Join SPF Events, Fundraisers & Connections to help raise awareness, funds, and crucial resources to serve our community.

  • Get your SPF swag here!

  • Donate to fund medical research using any one of the many ways, platforms, or services that helps SPF.

  • Here's the latest issue and more

News & Announcements

June 5, 2023
byWheelchair Travel, John Morris
May 31, 2023
byPaige Twenter, Clinical Leadership and Infection Control
May 17, 2023
byJonathan R. Brent and Han-Xiang Deng
May 6, 2023
byEva M J de Boer, Balint S de Vries, Maartje Pennings, Erik-Jan Kamsteeg, Jan H Veldink, Leonard H van den Berg, Michael A van Es
May 6, 2023
byGautam Wali, Sue-Faye Siow, Erandhi Liyanage, Kishore R Kumar, Alan Mackay-Sim, Carolyn M Sue
April 10, 2023
byYongchao Mou, Ghata Nandi, Sukhada Mukte, Eric Chai, Zhenyu Chen, Jorgen E. Nielsen, Troels T. Nielsen, Chiara Criscuolo, Craig Blackstone, Matthew J. Fraidakis & Xue-Jun Li

The Spastic Paraplegia Foundation, Inc. is a nonprofit corporation under section 501(c)(3) of the U.S. Internal Revenue Code, EINTax ID#: 04-3594491

Seal of Transparency and Combined Federal Campaign

  • I've been dealing with Hereditary Spastic Paraplegia affecting my SPG7 for a very (very) long time and I was doing very well for myself. Then, recently, I joined a few support groups here in Ottawa and I found the Spastic Paraplegia Foundation and met a bunch of like-minded people. I put myself out there as an ambassador for Canada. Hopefully I can spread awareness, get other Canadians to join the Foundation and share my story with others.

    Linda Lafontaine

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