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Welcome to Spastic Paraplegia Foundation, Inc.

SPF Vision

The day when all individuals with HSP or PLS are diagnosed, treated, and cured.

HSP and PLS are neurological disorders affecting the voluntary muscles. The disorders are progressive and may lead to patients being unable to walk, and more. The Spastic Paraplegia Foundation is dedicated to advancing research and finding cures for two groups of closely related, progressive neurological disorders: Primary Lateral Sclerosis (PLS) and Hereditary Spastic Paraplegia (HSP).

Learn about our process to fund research for HSP and PLS here.

News & Announcements

A total of 1930 search results were identified, and 1437 abstracts were screened after duplicates were removed, of which 1222 were identified as irrelevant. The full texts of the remaining results (n = 215) were assessed according to inclusion criteria. Ten more studies were identified by searching the references of the included articles

The Spastic Paraplegia Foundation, Inc. is a nonprofit corporation under section 501(c)(3) of the U.S. Internal Revenue Code, EINTax ID#: 04-3594491

Seal of Transparency and Combined Federal Campaign
  • I've been dealing with Hereditary Spastic Paraplegia affecting my SPG7 for a very (very) long time and I was doing very well for myself. Then, recently, I joined a few support groups here in Ottawa and I found the Spastic Paraplegia Foundation and met a bunch of like-minded people. I put myself out there as an ambassador for Canada. Hopefully I can spread awareness, get other Canadians to join the Foundation and share my story with others.

    Linda Lafontaine