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HSP & PLS
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Overview
What is an hereditary disorder?
HSP
About HSP
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SPG Numbers and Molecular Pathways
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Treatments and Therapies
PLS
SPF Role in PLS Research
PLS Overview
Almost everything you wanted to know about PLS in four minutes
Juvenile PLS
A Work in Progress
Articles/Papers/Studies
Differences between HSP and PLS
Get Involved
Overview
SPF Survey on HSP/PLS
HSP and PLS Survey Results
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The Power of 12: You’ve Been Challenged
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Overview
July 8, 2026
Advocacy
Overview
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Kids & Teens with HSP
Childhood Onset HSP
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Kids and Teens with HSP
HSP Childhood Onset Survey 2022
HSP Childhood Onset Survey 2026
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Overview
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Overview
Join/Update
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Genetic Testing
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HSP San Diego
Bespoke Genetic Medicines - CureSPG75
Our Partner Organizations
Overview
Patient Worthy
Global Genes
Euro-HSP
AEPEF
ASPEC Brasil
Self Help Guides
Stretching and Exercises
Surgical Anesthesia in HSP and PLS
Incontinence
Accessible Parking
Miscellaneous
Newsletter
Synapse
HSP & PLS Informational Documents
Government Aid & Charity Programs
SPF YouTube Channel
Research
Overview
SP-CERN
SP-CERN
SP-CERN LOCATIONS
SP-CERN Research
Current Studies Seeking Participants
Completed Research
Completed Research
Imaging of neuro-inflammation in PLS, HSP, and ALS
Mapping Cortical and Subcortical Degeneration in PLS
Research Grants Funded
Research Grants Funded in 2025
Research Grants Funded between 2021 - 2024
Research Grants Funded Between 2003 - 2020
Submit Proposal
Invitae SP/PLS Insights Network
The Foundation
Overview
Our History
Board of Directors
Scientific Advisory Board
Corporate Documents
Media
Public Service Announcements
Rare Disease Day at NIH 2026
October 17: World HSP/PLS Day
All About World HSP & PLS Day
World HSP & PLS Day
World Day Videos
World Day Symbol
News Article Archive
News Articles
February
22
,
2025
Extremely Low-Frequency and Low-Intensity Electromagnetic Field Technology (ELF-EMF) Sculpts Microtubules
by
Alexandra Lobyntseva, Maram Ganaiem, Yanina Ivashko-Pachima, Colin J. Barnstable, Batsheva Weisinger, Ana Parabucki, Yaron Segal, Esther Shohami, Illana Gozes
February
5
,
2025
Spinal stimulation restored muscles wasted by rare genetic disorder
by
Jon Hamilton, Rhode Island PBS
January
23
,
2025
The Top Stories That Defined Exoskeleton Technology in 2024
by
The Exoskeleton Report 1/6/25
December
27
,
2024
Restoring adapter protein complex 4 function with small molecules: an in silico approach to spastic paraplegia 50
by
Serena Francisco | Lorenzo Lamacchia | Attilio Turco | Giuseppe Ermondi | Giulia Caron | Matteo Rossi Sebastiano
October
18
,
2024
Axon-specific microtubule regulation drives asymmetric regeneration 2 of sensory neuron axons
by
Ana C. Costa, Blanca R. Murillo, Rita Bessa, Ricardo Ribeiro, Tiago Ferreira da Silva, Patrícia Porfírio-Rodrigues , Gabriel G. Martins , Pedro Brites , Matthias Kneussel, Thomas Misgeld, Monika S. Brill , Monica M. Sousa
September
13
,
2024
YouTube Video: What is Hereditary Spastic Paraplegia
by
Patrick Malone
September
10
,
2024
Dayna (with HSP) defeats demons to claim Bronze in Paris
by
Marcus Uhe, Berwick Star News
September
5
,
2024
Pittsburgh Native , Rebecca Hart (with HSP). Wins Gold Medal In 2024 Paralympics
by
Eric Heyl, Pittsburg News
August
22
,
2024
Preclinical alternative drug discovery programs for monogenic rare diseases. The case of hereditary spastic paraplegias
by
Matteo Rossi Sebastiano, Shinji Hadano, Fabrizia Cesca, Giuseppe Ermondi
August
17
,
2024
Create Your Legal Fee Will and Legacy! August is National Make-A-Will Month!
by
FreeWill
July
3
,
2024
A Wheelchair User’s Guide to Shoulder Treatments
by
Bob Vogel, New Mobility Magazine
July
1
,
2024
The Journey of CRISPR-Cas9, The past, present, and future of gene editing
by
Jon Chesnut, The Medicine Maker
July
1
,
2024
Researchers Publish 'Revolutionary' Gene Editing Findings
by
Sean Ashcroft, Healthcare Digital
June
30
,
2024
Neurodegeneration Due to Ultra-Rare Disease (SPG50 HSP) Slowed by AAV Gene Therapy
by
Genetic Engineering and Biotechnology News
June
27
,
2024
Download recent PhD Dissertation: MECHANISMS LINKING MITOCHONDRIAL DYNAMICS, MICROTUBULE MOTORS, AND NEUROLOGICAL DISEASE
by
Adam Ray Fenton, University of Pennsylvania
June
21
,
2024
MorphGrower: A Synchronized Layer-by-layer Growing Approach for Plausible Neuronal Morphology Generation
by
Nianzu Yang Kaipeng Zeng Haotian Lu Yexin Wu Zexin Yuan Dan
June
17
,
2024
Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons
by
Eliska Zlamalova, Catherine Rodger, Francesca Greco, Samuel R. Cheers, Julia Kleniuk, Aishwarya G. Nadadhur, Zuzana Kadlecova, Evan Reid
June
17
,
2024
Mobile digital gait analysis captures effects of botulinum toxin in hereditary spastic paraplegia
by
Alzhraa A Ibrahim, Malte Ollenschläger, Stephan Klebe, Rebecca Schüle, Nicole Jeschonneck, Melanie Kellner, Evelyn Loris, Teresa Greinwalder, Bjoern M Eskofier, Jürgen Winkler, Heiko Gaßner, Martin Regensburger
June
17
,
2024
Decreasing ganglioside synthesis delays motor and cognitive symptom onset in Spg11 knockout mice
by
Manon Fortier, Margaux Cauhapé, Suzie Buono, Julien Becker, Alexia Menuet, Julien Branchu, Ivana Ricca, Serena Mero, Karim Dorgham, Khalid-Hamid El Hachimi, Kostantin Dobrenis, Benoit Colsch, Dominic Samaroo, Morgan Devaux, Ale
June
11
,
2024
Recap Wearable Technologies Conference EU 2024
by
Wearable Technologies Online Magazine
June
11
,
2024
Medicare Sets Reimbursement Rates for Personal Exoskeletons: A Milestone for Accessibility
by
Exoskeleton Report
April
26
,
2024
The journey to a treatment for hereditary spastic paraplegia
by
Nancy Fliesler, Boston Children's Hospital
April
15
,
2024
Columbia gets $15M to design gene therapies for rare ALS forms
by
ALS News Today
April
15
,
2024
The Best Small Town in Each State
by
Bradley O'Neil, The Discover
April
12
,
2024
Cross-Sectional Analysis of Exome Sequencing Diagnosis in Patients With Neurologic Phenotypes Facing Barriers to Clinical Testing
by
Yue-Ting Deng, Bang-Sheng Wu, Liu Yang, Xiao-Yu He, Ju-Jiao Kang, Wei-Shi Liu, Ze-Yu Li, Xin-Rui Wu, Ya-Ru Zhang, Shi-Dong Chen, Yi-Jun Ge, Yu-Yuan Huang, Jian-Feng Feng, Ying Zhu, Qiang Dong, Ying Mao, Wei Cheng & Jin-Tai Yu
HSP & PLS
New to SPF?
Welcome!
Website Tour
Join/Update
Overview
What is an hereditary disorder?
HSP
About HSP
Genetic Information
SPG Numbers and Molecular Pathways
Videos/Blogs/Podcasts
Articles/Papers/Studies
Treatments and Therapies
PLS
SPF Role in PLS Research
PLS Overview
Almost everything you wanted to know about PLS in four minutes
Juvenile PLS
A Work in Progress
Articles/Papers/Studies
Differences between HSP and PLS
Get Involved
Overview
SPF Survey on HSP/PLS
HSP and PLS Survey Results
Donate Here
Many Ways to Donate
The Power of 12: You’ve Been Challenged
Current Fundraising Campaigns
Estate Planning & Wills
Memorial Giving Honoring Love Ones
Become a Corporate Sponsor
Events
Events Calendar
List of Events
Annual Conference
Overview
Annual Conference Sponsorships
Past Annual Conferences
Local Events and Fundraisers
5K Run, Walk Roll
Overview
Potato Pants
Past Events / Fundraisers / Connections
SPF Talks
Overview
July 8, 2026
Advocacy
Overview
How to Help
Current Campaigns
Related Organizations & Podcasts
Brain & Spinal Cord Donation
Spreading Awareness
Kids & Teens with HSP
Childhood Onset HSP
Kids and Teens with HSP Hanbooks
Kids and Teens with HSP
HSP Childhood Onset Survey 2022
HSP Childhood Onset Survey 2026
Current Studies Seeking Participants
Ambassadors
Overview
Ambassador Volunteer Information
Support Groups
Volunteer on a Committee
SPF Store
Resources
Overview
Join/Update
Directories
Ambassadors
Physician/Clinic Directory
Physical Therapists
Genetic Testing and International Organizations
Genetic Testing
International Organizations
Helpful Websites
HSP San Diego
Bespoke Genetic Medicines - CureSPG75
Our Partner Organizations
Overview
Patient Worthy
Global Genes
Euro-HSP
AEPEF
ASPEC Brasil
Self Help Guides
Stretching and Exercises
Surgical Anesthesia in HSP and PLS
Incontinence
Accessible Parking
Miscellaneous
Newsletter
Synapse
HSP & PLS Informational Documents
Government Aid & Charity Programs
SPF YouTube Channel
Research
Overview
SP-CERN
SP-CERN
SP-CERN LOCATIONS
SP-CERN Research
Current Studies Seeking Participants
Completed Research
Completed Research
Imaging of neuro-inflammation in PLS, HSP, and ALS
Mapping Cortical and Subcortical Degeneration in PLS
Research Grants Funded
Research Grants Funded in 2025
Research Grants Funded between 2021 - 2024
Research Grants Funded Between 2003 - 2020
Submit Proposal
Invitae SP/PLS Insights Network
The Foundation
Overview
Our History
Board of Directors
Scientific Advisory Board
Corporate Documents
Media
Public Service Announcements
Rare Disease Day at NIH 2026
October 17: World HSP/PLS Day
All About World HSP & PLS Day
World HSP & PLS Day
World Day Videos
World Day Symbol
Join/Update
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