February 9, 2026

SPF Talks

with Dr Ikjae Lee on PLS NATURAL HISTORY STUDY

Monday, Februrary, 2026 at 12:00 pm CST

Bring your questions!

AUDIENCE: This SPF TALKS is intended for EVERYONE.

INVITATION: You are invited to a Zoom meeting with Dr Ikjae Lee presenting the outcomes from the PLS NHS from the 2 year follow up and continuing support for the PLS NHS extension study through which a collection of long-term evolution of function and diagnosis in this cohort and develop biomarkers. 

WHEN: February 9, 2026, Monday, 12:00 pm Central Time

REGISTER: You must register in advance for this meeting: CLICK REGISTER BUTTON. After registering, you will receive a confirmation email containing information about joining the meeting.

Objective: The primary lateral sclerosis (PLS) consensus diagnostic criteria and functional rating scale (PLSFRS) were recently established to facilitate and optimize future PLS clinical trials. We examined the trajectory of the PLSFRS and other functional outcome measures and biomarkers in the PLS Natural History Study (PLS NHS) to understand their performance in this prospective cohort.

Interpretation: In PLS, the rate of functional decline, as measured by the PLSFRS total score, is faster during the early phase of the disease. Neurofilament light might serve as a prognostic biomarker in PLS.

Ikjae Lee, MD
Assistant professor
PLS NATURAL HISTORY STUDY:
PLSFRS AND OTHER OUTCOMES
Eleanor & Lou Gehrig ALS Center
Columbia University Irving Medical Center
New York, NY