2022
I. HSP Grants
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"Antisense Oligonucleotide Therapy for SPG4-HSP"
New Treatment Strategy for SPG4-HSP. -
Stefan Barakat M.D., Ph.D, Clinical Genetics, Erasmus University, Rotterdam, The Netherlands"Exploring therapeutic avenues for a new type of HSP caused by mutations in AMFR: a pilot towards therapy."
Finding a potential therapy for a rare new form of Hereditary Spastic Paraplegia. -
Laura Civiero, Ph.D. Associate Professor of Physiology, University of Padova, Italy"Finding novel approaches to rescue pathological phenotypes in ATP13A2-linked Hereditary Spastic Paraplegia."
Finding novel therapeutic approaches in Hereditary Spastic Paraplegia. -
Matthias Kneussel, Ph.D., University Medical Center Hamburg-Eppendorf, Germany"Investigating Connections between Tubulin Posttranslational Modifications, Tubular ER Network Integrity and Hereditary Spastic Paraplegia-Related Proteins in Axons."
How Hereditary Spastic Paraplegia Proteins May Regulate Microtubule-ER Crosstalk for Axonal Health. -
Claire Pujol, Ph.D, CNRS researcher, Pasteur Institute, Paris, France"Molecular dissection of mitochondrial dysfunction in HSP by unbiased imaging-based pharmacological and genetic screening."
Mitochondrial Side Story of HSP disease.
II. PLS Grants
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Mukesh Gautam, Ph.D, Northwestern University"Revealing ultrastructural defects in the motor cortex of PLS patients with and without TDP-43 pathology"
Revealing cellular problems in the PLS brain.
2021
I. HSP Grants
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Frederic Darios, Ph.D., and Alexandra Durr, MD, Ph.D. - ICM-Paris Brain Institute, Paris, FranceModulation of mitochondrial function as a modifier of SPG4 physiopathology..
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Jonathon Howard, Ph.D, Eugene Higgins Professor of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT.“Roles of alternate isoforms of spastin on function in vitro and in vivo”
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Roberta La Piana, MD, PhD, Assistant Professor, McGill University, Montreal, QC, Canada"Identifying novel white matter diagnostic criteria and imaging biomarkers in Hereditary Spastic Paraplegias (HSPs)”.
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P. Hande Ozdinler, Ph.D., Associate Professor, Northwestern University, Feinberg School of Medicine, Chicago, IL"Investigation of NU-9 and its impact on upper motor neurons diseased by spastin mutations in HSP”
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"Gene therapy, approach forSPG4-based Hereditary Spastic Paraplegia"
II. PLS Grants
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"Characterizing infratentorial pathology in PLS: the longitudinal evaluation of spinal cord, brainstem and cerebellar pathology in vivo".
By clicking on Dr. Bede's name above, a compressed file will be downloaded to your computer. -
Marka van Blitterswijk, M.D., Ph.D., Associate Professor of Neuroscience, Mayo Clinic Jacksonville, FL"Revealing determents of PLS with long read sequencing”.
Our Impact since our inception...
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Dollars Raised
Over 12,000,000 dollars for research!
